Diplomacy pushes Gaza peace momentum forward

JERUSALEM (AP) —

A diplomatic push to end Israel's nearly weeklong offensive in the Gaza Strip gained momentum Tuesday, with Egypt's president predicting that airstrikes would soon end, the U.S. secretary of state racing to the region and Israel's prime minister saying his country would be a "willing partner" to a cease-fire with the Islamic militant group Hamas.

As international diplomats worked to cement a deal, a senior Hamas official said an agreement was close even as relentless airstrikes and rocket attacks between the two sides continued. The Israeli death toll rose to five with the deaths Tuesday of an Israeli soldier and a civilian contractor. More than 130 Palestinians have been killed.

U.S. Secretary of State Hillary Rodham Clinton held a late-night meeting with Israeli Prime Minister Benjamin Netanyahu after rushing to the region from Cambodia, where she had accompanied President Barack Obama on a visit.

"The goal must be a durable outcome that promotes regional stability and advances the security and legitimate aspirations of Israelis and Palestinians alike," she said at a news conference with Netanyahu.

Netanyahu said Israel would welcome a diplomatic solution to the crisis but threatened further military activity, saying he was ready to take "whatever action" is necessary.

The comments came after conflicting reports on whether a deal was imminent.

"We haven't struck the deal yet, but we are progressing and it will most likely be tonight," Moussa Abu Marzouk said earlier Tuesday from Cairo, where cease-fire talks were being held. A second Hamas official, Izzat Risheq, said later that a deal might not be reached.

Israeli officials said only that "intensive efforts" were under way to end the fighting. Israeli media quoted Defense Minister Ehud Barak as telling a closed meeting that Israel wanted a 24-hour test period of no rocket fire to see if Hamas could enforce a truce.

In what appeared to be a last-minute burst of heavy fire, Israeli tanks and gunboats shelled targets late Tuesday, and an airstrike killed two brothers riding on a motorcycle. The men weren't identified.

Egyptian President Mohammed Morsi, perhaps the most important interlocutor between Hamas, which rules the Palestinian territory, and the Israelis, said the negotiations between the two sides would yield "positive results" during the coming hours.

Israel demands an end to rocket fire from Gaza and a halt to weapons smuggling into Gaza through tunnels under the border with Egypt. It also wants international guarantees that Hamas will not rearm or use Egypt's Sinai region, which abuts both Gaza and southern Israel, to attack Israelis.

Hamas wants Israel to halt all attacks on Gaza and lift tight restrictions on trade and movement in and out of the territory that have been in place since Hamas seized Gaza by force in 2007. Israel has rejected such demands in the past.

In Brussels, a senior official of the European Union's foreign service said a cease-fire would include an end of Israeli airstrikes and targeted killings in Gaza, the opening of Gaza crossing points and an end to rocket attacks on Israel. The official spoke on condition of anonymity because he was not authorized to speak to the media.

Violence raged on as the talks continued. An airstrike late Tuesday killed two journalists who work for the Hamas TV station, Al-Aqsa, according to a statement from the channel. The men were in a car hit by an airstrike, Gaza health official Ashraf al-Kidra said. Israel claims that many Hamas journalists are involved in militant activities. Earlier this week it targeted the station's offices, saying it served as a Hamas communications post.

By Tuesday, 133 Palestinians, including at least 54 civilians, were killed since Israel began an air onslaught that has so far included nearly 1,500 strikes. Some 840 people have been wounded, including 225 children, Gaza health officials said.

Five Israelis, including an 18-year-old soldier and a civilian contractor who worked for the military struck by rocket fire Tuesday, have also been killed and dozens wounded since the fighting began last week, the numbers possibly kept down by a rocket-defense system that Israel developed with U.S. funding. More than 1,000 rockets have been fired at Israel this week, the military said.

Late Tuesday, a Palestinian rocket hit a house in the central Israeli city of Rishon Lezion, wounding two people and badly damaging the top two floors of the building, police spokesman Micky Rosenfeld said. In other violence, a 60-year-old Israeli woman was seriously wounded in a firebombing attack as she drove in the West Bank, police said.

With the death toll rising, the international community stepped up efforts to bring a halt to the fighting that began last Wednesday with an Israel's assassination of the Hamas military chief.

"If a long-term solution can be put in place through diplomatic means, then Israel would be a willing partner to such a solution. But if stronger military action proves necessary to stop the constant barrage of rockets, Israel wouldn't hesitate to do what is necessary to defend our people," Netanyahu said during a joint press conference in Jerusalem with visiting U.N. chief Ban Ki-moon.

Ban condemned Palestinian rocket attacks, but urged Israel to show "maximum restraint."

"Further escalation benefits no one," he said.

Minutes before Ban's arrival in Jerusalem from Egypt, Palestinian militants fired a rocket toward Jerusalem, just the second time it has targeted the city. The rocket fell in an open area southeast of the city.

Jerusalem had previously been considered beyond the range of Gaza rockets — and an unlikely target because it is home to the Al-Aqsa Mosque compound, Islam's third-holiest shrine.

Earlier Tuesday, a man identified as Hamas' militant commander urged his fighters to keep up attacks on Israel. Speaking from hiding on Hamas-run TV and radio, Mohammed Deif said Hamas "must invest all resources to uproot this aggressor from our land," a reference to Israel.

Israeli warplanes dropped leaflets on several Gaza neighborhoods asking residents to evacuate and head toward the center of Gaza City along specific roads. The army "is not targeting any of you, and doesn't want to harm you or your families," the leaflets said. Palestinian militants urged residents to ignore the warnings, calling them "psychological warfare."

The Israeli military relies on a network of informants to identify its targets. Masked gunmen publicly shot dead six suspected collaborators with Israel in a large Gaza City intersection Tuesday, witnesses said. An Associated Press reporter saw a mob surrounding five of the bloodied corpses shortly after the killing.

Clinton was also scheduled to meet with Palestinian President Mahmoud Abbas in the West Bank and Egyptian leaders in Cairo on Wednesday. Turkey's foreign minister and a delegation of Arab League foreign ministers traveled to Gaza on a separate truce mission. Airstrikes continued to hit Gaza even as they entered the territory.

"Turkey is standing by you," Turkish Foreign Minister Ahmet Davutoglu told the Hamas prime minister in Gaza, Ismail Haniyeh. "Our demand is clear. Israel should end its aggression immediately and lift the inhumane blockade imposed on Gaza."

It was unclear how diplomatic efforts to achieve a cease-fire and stave off a threatened Israeli ground invasion into Gaza were hampered by the hard-to-bridge positions staked out by both sides — and by the persistent attacks. Thousands of Israeli soldiers have been dispatched to the Gaza border in case of a decision to invade.

The U.S. considers Hamas, which has killed hundreds of Israelis in suicide and other attacks, to be a terror group and does not meet with its officials. The Obama administration blames Hamas for the latest eruption of violence and says Israel has the right to defend itself. At the same time, it has warned against a ground invasion, saying it could send casualties spiraling.

The conflict erupted last week, when a resurgence in rocket fire from Gaza set off the Israeli offensive, which included hundreds of airstrikes on militants' underground rocket launchers and weapons' stores.

The onslaught turned deadlier over the weekend, as airstrikes began targeting the homes of suspected Hamas activists, leading to a spike in civilian casualties. Hamas is deeply rooted in densely populated Gaza, and the movement's activists live in the midst of ordinary Gazans. Israel says militants are using civilians as human shields, both for their own safety and to launch rocket strikes from residential neighborhoods.

The conflict showed signs of spilling into the West Bank, as hundreds of Palestinian protesters in the town of Jenin clashed with Israeli forces during a demonstration against Israel's Gaza offensive.

Two Palestinian protesters were killed in anti-Israel demonstrations in the West Bank on Monday, according to Palestinian officials. Separate clashes occurred Tuesday in Ramallah, the seat of the Palestinian government, during the funeral for one of the dead.

Palestinian President Mahmoud Abbas, who lost control of Gaza to Hamas in 2007, now governs from the West Bank. Abbas claims to represent both areas, and there is widespread sympathy among West Bank Palestinians for their brethren in Gaza.

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Barzak reported from Gaza City, Gaza Strip. Associated Press writers Hamza Hendawi in Cairo, and Karin Laub in Gaza City contributed to this report.

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Obama makes history with Myanmar, Cambodia visits

PHNOM PENH, Cambodia (AP) — On a history-making trip, President Barack Obama on Monday paid the first visit by an American leader to Myanmar and Cambodia, two Asian countries with troubled histories, one on the mend and the other still a cause of concern.

Obama's fast-paced, pre-Thanksgiving trip vividly illustrated the different paths the regional neighbors are taking to overcome legacies of violence, poverty and repression.

Cheered by massive flag-waving crowds, Obama offered long-isolated Myanmar a "hand of friendship" as it rapidly embraces democratic reforms. Hours later, he arrived in Cambodia to little fanfare, then pointedly criticized the country's strongman leader on the issue of human rights during a tense meeting.

Obama was an early champion of Myanmar's sudden transformation to civilian rule following a half-century of military dictatorship. He's rewarded the country, also known as Burma, with eased economic penalties, increased U.S. investment and now a presidential visit, in part to show other nations the benefits of pursuing similar reforms.

"You're taking a journey that has the potential to inspire so many people," Obama said during a speech at Myanmar's University of Yangon.

The Cambodians are among those Obama is hoping will be motivated. White House officials said he held up Myanmar, a once-pariah state, as a benchmark during his private meeting Monday evening with Prime Minister Hun Sen, the autocratic Cambodian leader who has held power for nearly 30 years. Hun Sen's rivals have sometimes ended up in jail or in exile.

Unlike the arrangement after Obama's meetings with Myanmar's President Thein Sein and democracy leader Aung Sun Suu Kyi, the U.S. and Cambodian leaders did not speak to the press following their one-on-one talks. They did step before cameras briefly before their meeting to greet each other with a brisk handshake and little warmth.

In private, U.S. officials said, Obama pressed Hun Sen to release political prisoners, stop land seizures and hold free and fair elections. Aides acknowledged the meeting was tense, with the Cambodian leader defending his practices, even as he professed to seek a deeper relationship with the U.S.

Ben Rhodes, Obama's deputy national security adviser, said the president told Hun Sen that without reforms, Cambodia's human rights woes would continue to be "an impediment" to that effort.

White House officials emphasized that Obama would not have visited Cambodia had it not been hosting two regional summit meetings the U.S. attends, a rare admonishment of a country on its own soil.

The Cambodian people appeared to answer Obama's cold shoulder in kind. Just a few small clusters of curious Cambodians gathered on the streets to watch his motorcade speed though the streets of Phnom Penh.

A welcome sign did greet Obama upon his arrival — but it heralded Chinese Premier Wen Jiabao, not the American president.

Human rights groups fear that because Obama delivered his condemnation of Hun Sen in private, government censors will keep his words from reaching the Cambodian people. And they worry the prime minister will then use Obama's visit to justify his grip on power and weaken the will of opposition groups.

"If Hun Sen's narrative about this visit is allowed to gel, it will create a perception that the United States and other international actors stand with Hun Sen, and not with the Cambodian people," said John Sifton, Asia director at Human Rights Watch. "It will be a tremendous blow to Cambodians who challenge his rule."

Obama's visit to Myanmar was also viewed critically by some international organizations, which saw the trip as a premature reward for a country that still holds political prisoners and has been unable to contain ethic violence.

Aware of that criticism, Obama tempered some of his praise for Myanmar during his six-hour visit. He underscored that the reforms that have taken hold over the past year are "just the first steps on what will be a long journey."

Perhaps the sharpest calls for caution came from Suu Kyi, Myanmar's longtime democracy champion. After meeting with Obama at the home where she spent years under house arrest, she warned that the most difficult part of the transition will be "when we think that success is in sight."

"Then we have to be very careful that we're not lured by the mirage of success," Suu Kyi said, speaking with Obama by her side.

The president, winding down his first foreign trip after winning re-election, had meetings scheduled in Cambodia Tuesday with his counterparts in the East Asia Summit. Obama has added the summit to his annual list of high-priority international meetings as he seeks to expand U.S. influence in the region.

Obama will also meet separately on the sidelines of the summit with Japanese Prime Minister Yoshihiko Noda and with Wen, the Chinese premier. It's likely to be Obama's last bilateral meetings with both men.

Noda dissolved his country's parliament last week, setting the stage for new elections his party is unlikely to win. And China is undergoing its first leadership transition in a decade, with Wen and President Hu Jintao stepping down to clear the way for new leaders in the country's Communist Party.

Obama will return to Washington before dawn Wednesday, in time for the ceremonial pardoning of the Thanksgiving turkey.

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Associated Press writers Jim Kuhnhenn and Grant Peck contributed to this report.

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Follow Julie Pace at http://twitter.com/jpaceDC

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MTV special profiles young people with HIV

NEW YORK (AP) — MTV is airing a special next week with profiles of three young people who have the HIV infection, amid worries that some people are taking the condition too casually.

The special, "I'm Positive," is scheduled to air Dec. 1 at 7 p.m. ET/PT. Drew Pinsky, who is one of the show's producers, said that if it does well, he hopes it can become a regular series.

In three decades, infection with the virus that causes AIDS has gone from a virtual death sentence to a chronic condition that can be controlled with early detection and a drug regimen. But even if it doesn't develop into full-blown AIDS, there's still some doubt about the long-term health implications of living with HIV and the drugs designed to keep control of it, Pinsky said.

"People are taking it too casually ... and forgetting about it," Pinsky said.

A generational divide is evident in the profiles on "I'm Positive." California girl Kelly, one of the three subjects, feels in control of the situation despite her infection. The mother of Stephanie, a single Southern girl infected through one instance of unprotected sex, is distraught and thinks her daughter is about to die.

The third profile subject, Otis, had a hard time telling his family that he was HIV positive since it was only a year earlier that he revealed he was gay.

As proven by its programming on teenage pregnancy, MTV finds that this documentary-style programming is a good way to reach its young viewers with a message.

"Young people relate when they see their peers struggling with this phenomenon," Pinsky said.

MTV began running "safe sex" campaigns in 1985, and has been encouraging youngsters to get themselves tested for 15 years in an effort funded together with the Kaiser Family Foundation.

Two in five people infected with HIV each year in the United States are between the ages of 13 and 29, MTV's targeted audience. More than 1.1 million Americans are living with HIV infection, according to the Centers for Disease Control.

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MTV is owned by Viacom Inc.

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EU drug regulator OKs Novartis' meningitis B shot

LONDON (AP) — Europe's top drug regulator has recommended approval for the first vaccine against meningitis B, made by Novartis AG.

There are five types of bacterial meningitis. While vaccines exist to protect against the other four, none has previously been licensed for type B meningitis. In Europe, type B is the most common, causing 3,000 to 5,000 cases every year.

Meningitis mainly affects infants and children. It kills about 8 percent of patients and leaves others with lifelong consequences such as brain damage.

In a statement on Friday, Andrin Oswald of Novartis said he is "proud of the major advance" the company has made in developing its vaccine Bexsero. It is aimed at children over two months of age, and Novartis is hoping countries will include the shot among the routine ones for childhood diseases such as measles.

Novartis said the immunization has had side effects such as fever and redness at the injection site.

Recommendations from the European Medicines Agency are usually adopted by the European Commission. Novartis also is seeking to test the vaccine in the U.S.

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Children of Gaza caught in the crossfire

GAZA (Reuters) - Barefoot boys chase each other in circles around the street, pointing pretend guns made out of rubber pipes up at the Gaza sky, which is thick with Israeli F-16s and surveillance drones.

"We're not afraid of the Jews' bombs!" said Sharif al-Ewad, whose plump cheeks make him look younger than his 15 years. "Al-Qassam (Hamas's armed wing) has raised its head high, and is really beating them up this time!" he smiled.

But beneath the swagger and bravado there is also a yearning for peace and quiet after five days of Israeli airstrikes that killed at least 65 Palestinians, including 20 children.

With one of the youngest populations in the world, over half of Gaza's 1.7 million residents are aged under 18 and they have little to comfort them beside the heady local culture of armed struggle against Israel.

The Jewish state pulled its troops and settlers out of the coastal territory in 2005 but ever since has come under regular rocket fire from Islamist group Hamas and its allies in the Gaza Strip, which refuse to recognize Israel's right to exist.

Israel launched its latest widescale operation last Wednesday with the stated aim of putting a halt to the attacks.

Psychiatrist Hasan Zeyada says the constant exposure to shocking violence has left many children suffering trauma and all that it entails -- bed-wetting, nightmares, flashbacks, and fear of going out in public.

"Part of this is related to our culture and religion, which values sacrifice and duty. The other part is a kind of denial. it's normal to be scared, but in the messages they've watched and heard, they're taught just to show strength," said Zeyada, manager of the Gaza Community Mental Health Program.

"When there's no safe place to go, they respond naturally with denial. In a situation like Gaza's, the best families and the community can do for children is to keep them close and go about life as normally as possible," he said.

That isn't very easy.

SMALL VICTIMS

With schools shut while the fighting rages, some children express delight at their newfound freedom. "Of course we're happy!" squealed one boy, drawing out giggles from his mates.

Looking more serious, Sharif shook his head. "No, it's no good. We want to learn. It's boring, and our parents try to make us stay inside. But we're not scared," he insisted.

On the other side of the fence, Israeli schools are also shuttered within a 40-km radius of Gaza because of an incessant rain of incoming rockets, with children confined to their homes.

Tragically, some young Gazans will never get to see school.

Tamer, 1, and Joumana Abu Sefan, 3, were blasted from their beds by an Israeli strike early on Sunday. Their father Salama, blood gushing down his face from his owns wounds, rushed them to hospital, where they were pronounced dead.

Male relatives stared on in tears, women cried out and swooned while the little bodies were swaddled in white cloth and gauze was placed in their nostrils to keep still-flowing blood from staining their faces.

At their joint funeral march just hours later, Salama cradled their heads as uncles held them aloft at his side.

Green Hamas flags were suddenly draped over their shrouds, and the militant group's religious songs, playing in the background, announced that the tiny pair had achieved martyrdom and that heaven would be their reward.

"What does Israel want with their blood?" Salama heaved, inconsolable and seeming to sleepwalk through the spectacle.

For its part, Israel denies targeting civilians and says it is constantly warning residents, who it says are used by as human shields, away from areas where militants operate.

Abdullah Zumlot, 15, the first hints of moustache speckling his upper lip, scoffed at this as he loitered around the hospital where the Abu Sefan children were earlier carried away.

"It's not fair what we have to live through, we're not happy. All my family and I do is sit at home and watch the news 24 hours," he complained.

(Editing by Crispian Balmer)

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Obama: Historic Myanmar visit underscores progress

BANGKOK (AP) — On the eve of his landmark trip to Myanmar, President Barack Obama tried to assure critics that his visit was not a premature reward for a long-isolated nation still easing its way toward democracy.

"This is not an endorsement of the government," Obama said Sunday in Thailand as he opened a three-country dash through Asia. "This is an acknowledgement that there is a process under way inside that country that even a year and a half, two years ago, nobody foresaw."

Obama was set to become the first U.S. president to visit Myanmar with Air Force One scheduled to touch down in Yangon on Monday morning. Though Obama planned to spend just six hours in the country, the much-anticipated stop came as the result of a remarkable turnaround in the countries' relationship.

The president's Asia tour also marks his formal return to the world stage after months mired in a bruising re-election campaign. For his first postelection trip, he tellingly settled on Asia, a region he has deemed the region as crucial to U.S. prosperity and security.

Aides say Asia will factor heavily in Obama's second term as the U.S. seeks to expand its influence in an attempt to counter China.

China's rise is also at play in Myanmar, which long has aligned itself with Beijing. But some in Myanmar fear that China is taking advantage of its wealth of natural resources, so the country is looking for other partners to help build its nascent economy.

Obama has rewarded Myanmar's rapid adoption of democratic reforms by lifting some economic penalties. The president has appointed a permanent ambassador to the country, also known as Burma, and pledged greater investment if Myanmar continues to progress following a half-century of military rule.

But some human rights groups say Myanmar's government, which continues to hold hundreds of political prisoners and is struggling to contain ethnic violence, hasn't done enough to earn a personal visit from Obama.

Speaking from neighboring Thailand, Obama said Sunday he was under no illusions that Myanmar had done all it needed to do. But he said the U.S. could play a critical role in helping ensure the country doesn't slip backward.

"I'm not somebody who thinks that the United States should stand on the sidelines and not want to get its hands dirty when there's an opportunity for us to encourage the better impulses inside a country," Obama said during a joint press conference Sunday with Thailand's prime minister.

Even as Obama turned his sights on Asia, widening violence in the Middle East competed for his attention.

Obama told reporters Sunday that Israel had the right to defend itself against missile attacks from Gaza. But he urged Israel not to launch a ground assault in Gaza, saying it would put Israeli soldiers, as well as Palestinian citizens, at greater risk and hamper an already vexing peace process.

"If we see a further escalation of the situation in Gaza, the likelihood of us getting back on any kind of peace track that leads to a two-state solution is going to be pushed off way into the future," Obama said.

The ongoing violence is likely to trail Obama as he makes his way from Thailand to Myanmar to Cambodia, his final stop before returning to Washington early Wednesday.

Obama will meet separately in Myanmar with Prime Minister Thein Sein, who has orchestrated much of his country's recent reforms. The president will also meet with longtime Myanmar democracy activist Aung Sun Suu Kyi in the home where she spent years under house arrest.

The president, as he seeks to assuage critics, has trumpeted Suu Kyi's support of his outreach efforts, saying Sunday that she was "very encouraging" of his trip.

The White House says Obama will express his concern for the ongoing ethnic tensions in Myanmar's western Rakhine state, where more than 110,000 people — the vast majority of them Muslims known as Rohingya — have been displaced.

The U.N. has called the Rohingya — who are widely reviled by the Buddhist majority in Myanmar — among the world's most persecuted people.

The White House says Obama will press the matter Monday with Thein Sein, along with demands to free remaining political prisoners as the nation transitions to democracy.

The president will cap his trip to Myanmar with a speech at Rangoon University, the center of the country's struggle for independence against Britain and the launching point for many pro-democracy protests. The former military junta shut the dormitories in the 1990s fearing further unrest and forced most students to attend classes on satellite campuses on the outskirts of town.

Obama began his Asian tour on a steamy day in Bangkok with a visit to the Wat Pho Royal Monastery. In stocking feet, the president and Secretary of State Hillary Rodham Clinton walked around a golden statue of a sitting Buddha. The complex is a sprawling display of buildings with colorful spires, gardens and waterfalls.

Obama then paid a courtesy call to the ailing, 84-year-old U.S.-born King Bhumibol Adulyadej in his hospital quarters. The king, the longest serving living monarch, was born in Cambridge, Mass., and studied in Europe.

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Associated Press writer Jim Kuhnhenn contributed to this report.

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'Twilight' finale dawns with $141.3M weekend

LOS ANGELES (AP) — The sun has set on the "Twilight" franchise with one last blockbuster opening for the supernatural romance.

"The Twilight Saga: Breaking Dawn — Part 2" sucked up $141.3 million domestically over opening weekend and $199.6 million more overseas for a worldwide debut of $340.9 million, according to studio estimates Sunday.

The finale ranks eighth on the list of all-time domestic debuts, and leaves "Twilight" with three of the top-10 openings, joining 2009's "New Moon" (No. 7 with $142.8 million) and last year's "Breaking Dawn — Part 1" (No. 9 with $138.1 million).

Last May's "The Avengers" is No. 1 with $207.4 million. "Batman" is the only other franchise with more than one top-10 opening: last July's "The Dark Knight Rises" (No. 3 with $160.9 million) and 2008's "The Dark Knight" (No. 4 with $158.4 million).

Though "Twilight" still is a female-driven franchise, with girls and women making up 79 percent of the opening-weekend audience, the finale drew the biggest male crowds in the series. Action-minded guys had more to root for in the finale as Kristen Stewart, Robert Pattinson and Taylor Lautner join in a colossal battle to end the story of warring vampires and werewolves.

"Our male audience particularly has enjoyed this film," said Richie Fay, head of distribution for Lionsgate, whose Summit Entertainment banner releases the "Twilight" movies. "With the action scenes in this one, we're hoping the holdover business will reflect the fact that males have kind of found it out."

The movie also helped lift Lionsgate into the big leagues among Hollywood studios. Paced by its $400 million smash with "The Hunger Games" and now the "Twilight" finale, Lionsgate surpassed $1 billion at the domestic box office for the first time.

Some box-office watchers had expected the last "Twilight" movie to open with a franchise record the way the "Harry Potter" finale did last year with $169.2 million, the second-best domestic debut on the charts.

"I thought that for the final installment, it might eclipse the franchise record, but to look at $141.3 million and say that's a disappointment, that's kind of crazy," said Paul Dergarabedian, an analyst for box-office tracker Hollywood.com. "It's one of the most consistently performing franchises of all time."

The "Twilight" finale took over the No. 1 spot from Sony's James Bond adventure "Skyfall," which slipped to second-place with $41.5 million domestically in its second weekend. "Skyfall" raised its domestic total to $161.3 million.

The franchise's third film starring Daniel Craig as Bond, "Skyfall" began rolling out overseas in late October and has hit $507.9 million internationally at the box office. The film's global total climbed to $669.2 million, helping to lift Sony to its best year ever with $4 billion worldwide, topping the studio's $3.6 billion haul in 2009.

"Skyfall" passed the previous franchise high of $599.2 million worldwide for 2006's "Casino Royale."

Steven Spielberg and Daniel Day-Lewis' Civil War drama "Lincoln" expanded nationwide after a week in limited release and came in at No. 3 with $21 million. Distributed by Disney, "Lincoln" lifted its domestic haul to $22.4 million.

The comic drama "Silver Linings Playbook," released by the Weinstein Co., got off to a good start in limited release, taking in $458,430 in 16 theaters for a solid average of $28,652 a cinema. By comparison, the "Twilight" finale averaged $34,717 in 4,070 theaters.

"Silver Linings Playbook" stars Bradley Cooper, Jennifer Lawrence and Robert De Niro in a quirky romance involving a man fresh out of a psychiatric hospital and an emotionally troubled young widow.

Keira Knightley's period drama "Anna Karenina" also started well in limited release with $315,395 in 16 theaters, for an average of $19,712. The Focus Features film stars Knightley in the title role of Leo Tolstoy's tragic romance.

Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Hollywood.com. Where available, latest international numbers are also included. Final domestic figures will be released Monday.

1. "The Twilight Saga: Breaking Dawn — Part 2," $141.3 million ($199.6 million international).

2. "Skyfall," $41.5 million ($49.6 million international).

3. "Lincoln," $21 million.

4. "Wreck-It Ralph," $18.3 million ($4.8 million international).

5. "Flight," $8.6 million ($1 million international).

6. "Argo," $4.1 million ($8.7 million international).

7. "Taken 2," $2.1 million ($2 million international).

8. "Pitch Perfect," $1.3 million ($4.1 million international).

9. "Here Comes the Boom," $1.2 million ($2.5 million international).

10 (tie). "Cloud Atlas," $900,000 ($5 million international).

10 (tie). "Hotel Transylvania," $900,000 ($7.8 million international).

10 (tie). "The Sessions," $900,000.

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Estimated weekend ticket sales at international theaters (excluding the U.S. and Canada) for films distributed overseas by Hollywood studios, according to Rentrak:

1. "The Twilight Saga: Breaking Dawn — Part 2," $199.6 million.

2. "Skyfall," $49.6 million.

3. "Argo," $8.7 million.

4. "Hotel Transylvania," $7.8 million.

5. "Evangelion: 3.0 You Can (Not) Redo," $7.5 million.

6. "A Werewolf Boy," $6.8 million.

7. "Cloud Atlas," $5 million.

8. "Wreck-It Ralph," $4.8 million.

9. "Confession of Murder," $3.5 million.

10. "Rise of the Guardians," $3.1 million.

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Online:

http://www.hollywood.com

http://www.rentrak.com

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Universal and Focus are owned by NBC Universal, a unit of Comcast Corp.; Sony, Columbia, Sony Screen Gems and Sony Pictures Classics are units of Sony Corp.; Paramount is owned by Viacom Inc.; Disney, Pixar and Marvel are owned by The Walt Disney Co.; Miramax is owned by Filmyard Holdings LLC; 20th Century Fox and Fox Searchlight are owned by News Corp.; Warner Bros. and New Line are units of Time Warner Inc.; MGM is owned by a group of former creditors including Highland Capital, Anchorage Advisors and Carl Icahn; Lionsgate is owned by Lions Gate Entertainment Corp.; IFC is owned by AMC Networks Inc.; Rogue is owned by Relativity Media LLC.

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EU drug regulator OKs Novartis' meningitis B shot

LONDON (AP) — Europe's top drug regulator has recommended approval for the first vaccine against meningitis B, made by Novartis AG.

There are five types of bacterial meningitis. While vaccines exist to protect against the other four, none has previously been licensed for type B meningitis. In Europe, type B is the most common, causing 3,000 to 5,000 cases every year.

Meningitis mainly affects infants and children. It kills about 8 percent of patients and leaves others with lifelong consequences such as brain damage.

In a statement on Friday, Andrin Oswald of Novartis said he is "proud of the major advance" the company has made in developing its vaccine Bexsero. It is aimed at children over two months of age, and Novartis is hoping countries will include the shot among the routine ones for childhood diseases such as measles.

Novartis said the immunization has had side effects such as fever and redness at the injection site.

Recommendations from the European Medicines Agency are usually adopted by the European Commission. Novartis also is seeking to test the vaccine in the U.S.

Read More..

Obama: Historic Myanmar visit underscores democratic progress

BANGKOK (AP) — On the eve of his landmark trip to Myanmar, President Barack Obama tried to assure critics that his visit was not a premature reward for a long-isolated nation still easing its way toward democracy.

"This is not an endorsement of the government," Obama said Sunday in Thailand as he opened a three-country dash through Asia. "This is an acknowledgement that there is a process under way inside that country that even a year and a half, two years ago, nobody foresaw."

Obama was set to become the first U.S. president to visit Myanmar with Air Force One scheduled to touch down in Yangon on Monday morning. Though Obama planned to spend just six hours in the country, the much-anticipated stop came as the result of a remarkable turnaround in the countries' relationship.

The president's Asia tour also marks his formal return to the world stage after months mired in a bruising re-election campaign. For his first postelection trip, he tellingly settled on Asia, a region he has deemed the region as crucial to U.S. prosperity and security.

Aides say Asia will factor heavily in Obama's second term as the U.S. seeks to expand its influence in an attempt to counter China.

China's rise is also at play in Myanmar, which long has aligned itself with Beijing. But some in Myanmar fear that China is taking advantage of its wealth of natural resources, so the country is looking for other partners to help build its nascent economy.

Obama has rewarded Myanmar's rapid adoption of democratic reforms by lifting some economic penalties. The president has appointed a permanent ambassador to the country, also known as Burma, and pledged greater investment if Myanmar continues to progress following a half-century of military rule.

But some human rights groups say Myanmar's government, which continues to hold hundreds of political prisoners and is struggling to contain ethnic violence, hasn't done enough to earn a personal visit from Obama.

Speaking from neighboring Thailand, Obama said Sunday he was under no illusions that Myanmar had done all it needed to do. But he said the U.S. could play a critical role in helping ensure the country doesn't slip backward.

"I'm not somebody who thinks that the United States should stand on the sidelines and not want to get its hands dirty when there's an opportunity for us to encourage the better impulses inside a country," Obama said during a joint press conference Sunday with Thailand's prime minister.

Even as Obama turned his sights on Asia, widening violence in the Middle East competed for his attention.

Obama told reporters Sunday that Israel had the right to defend itself against missile attacks from Gaza. But he urged Israel not to launch a ground assault in Gaza, saying it would put Israeli soldiers, as well as Palestinian citizens, at greater risk and hamper an already vexing peace process.

"If we see a further escalation of the situation in Gaza, the likelihood of us getting back on any kind of peace track that leads to a two-state solution is going to be pushed off way into the future," Obama said.

The ongoing violence is likely to trail Obama as he makes his way from Thailand to Myanmar to Cambodia, his final stop before returning to Washington early Wednesday.

Obama will meet separately in Myanmar with Prime Minister Thein Sein, who has orchestrated much of his country's recent reforms. The president will also meet with longtime Myanmar democracy activist Aung Sun Suu Kyi in the home where she spent years under house arrest.

The president, as he seeks to assuage critics, has trumpeted Suu Kyi's support of his outreach efforts, saying Sunday that she was "very encouraging" of his trip.

The White House says Obama will express his concern for the ongoing ethnic tensions in Myanmar's western Rakhine state, where more than 110,000 people — the vast majority of them Muslims known as Rohingya — have been displaced.

The U.N. has called the Rohingya — who are widely reviled by the Buddhist majority in Myanmar — among the world's most persecuted people.

The White House says Obama will press the matter Monday with Thein Sein, along with demands to free remaining political prisoners as the nation transitions to democracy.

The president will cap his trip to Myanmar with a speech at Rangoon University, the center of the country's struggle for independence against Britain and the launching point for many pro-democracy protests. The former military junta shut the dormitories in the 1990s fearing further unrest and forced most students to attend classes on satellite campuses on the outskirts of town.

Obama began his Asian tour on a steamy day in Bangkok with a visit to the Wat Pho Royal Monastery. In stocking feet, the president and Secretary of State Hillary Rodham Clinton walked around a golden statue of a sitting Buddha. The complex is a sprawling display of buildings with colorful spires, gardens and waterfalls.

Obama then paid a courtesy call to the ailing, 84-year-old U.S.-born King Bhumibol Adulyadej in his hospital quarters. The king, the longest serving living monarch, was born in Cambridge, Mass., and studied in Europe.

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Associated Press writer Jim Kuhnhenn contributed to this report.

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Pakistan struggles in race to develop armed drones

KARACHI, Pakistan (AP) — Pakistan is secretly racing to develop its own armed drones, frustrated with U.S. refusals to provide the aircraft, but is struggling in its initial tests with a lack of precision munitions and advanced targeting technology.

One of Islamabad's closest allies and Washington's biggest rivals, China, has offered to help by selling Pakistan armed drones it developed. But industry experts say there is still uncertainty about the capabilities of the Chinese aircraft.

The development of unmanned combat aircraft is especially sensitive in Pakistan because of the widespread unpopularity of the hundreds of U.S. drone strikes against Taliban and al-Qaida militants in the country's rugged tribal region bordering Afghanistan.

The Pakistani government denounces the CIA strikes as a violation of the country's sovereignty, though senior civilian and military leaders are known to have supported at least some of the attacks in the past. Pakistani officials also call the strikes unproductive, saying they kill many civilians and fuel anger that helps militants recruit additional fighters — allegations denied by the U.S.

Pakistan has demanded the U.S. provide it with armed drones, claiming it could more effectively carry out attacks against militants. Washington has refused because of the sensitive nature of the technology and doubts that Pakistan would reliably target U.S. enemies. The U.S. has held talks with Pakistan about providing unarmed surveillance drones, but Islamabad already has several types of these aircraft in operation, and the discussions have gone nowhere.

Inaugurating a defense exhibition in the southern city of Karachi last week, Pakistani Prime Minister Raja Pervaiz Ashraf indicated Islamabad would look for help from Beijing in response to U.S. intransigence.

"Pakistan can also benefit from China in defense collaboration, offsetting the undeclared technological apartheid," said Ashraf.

Pakistan has also been working to develop armed drones on its own, said Pakistani military officials and civilians involved in the domestic drone industry, all of whom spoke on condition of anonymity because of the classified nature of the work.

Pakistan first began weapons tests seven or eight months ago with the Falco, an Italian drone used by the Pakistani air force for surveillance that has been modified to carry rockets, said a civilian with knowledge of the secret program. The military is also conducting similar tests with the country's newest drone, the Shahpur, he said. An unarmed version of the Shahpur was unveiled for the first time at the Karachi exhibition.

The weapons tests have been limited to a handful of aircraft, and no strikes have been carried out in combat, said the civilian.

Pakistan lacks laser-guided missiles like the Hellfire used on U.S. Predator and Reaper drones and the advanced targeting system that goes with it, so the military has been using unguided rockets that are much less accurate.

While Hellfire missiles are said to have pinpoint accuracy, the rockets used by Pakistan have a margin of error of about 30 meters (100 feet) at best, and an unexpected gust of wind could take them 300 meters (1,000 feet) from their intended target, said the civilian. Even if Pakistan possessed Hellfires and the guidance system to use them, the missile's weight and drag would be a challenge for the small drones produced by the country.

Pakistan's largest drone, the Shahpur, has a wingspan of about seven meters (22 feet) and can carry 50 kilograms (110 pounds). The U.S. Predator, which can be equipped with two Hellfire missiles, has a wingspan more than twice that and a payload capacity over four times as great.

Pakistani drones also have much more limited range than those produced in the U.S. because they are operated based on "line of sight" using radio waves, rather than military satellites. The Shahpur has a maximum range of 250 kilometers (150 miles), while the Predator can fly over five times that distance.

The British newspaper The Guardian reported Tuesday that Pakistan was working on an armed drone but did not provide details.

The market for drones has exploded in Pakistan and other countries around the world in recent years, as shown by the array of aircraft on display at the defense exhibition in Karachi. Hoping to tap into a worldwide market worth billions of dollars a year, public and private companies wheeled out over a dozen drones that ranged in size from hand-held models meant to be carried in a backpack to larger aircraft like the Shahpur.

All the Pakistani drones on display were advertised as unarmed and meant for surveillance only. One private company, Integrated Dynamics, even promotes its aircraft under the slogan "Drones for Peace." But several models developed by the Chinese government were marketed as capable of carrying precision missiles and bombs.

The Chinese government has offered to sell Pakistan an armed drone it has produced, the CH-3, which can carry two laser-guided missiles or bombs, industry insiders said.

Also being offered to Pakistan is a more advanced drone, the CH-4, which closely resembles a U.S. Reaper and can carry four laser-guided missiles or bombs, according to Li Xiaoli, a representative of the Chinese state-owned company that produces both the CH-3 and CH-4, Aerospace Long-march International Trade Co., Ltd.

Pakistan has yet to purchase any armed Chinese drones because their capabilities have yet to be proven, but is likely to do so in the future, said the civilian with knowledge of the Pakistani military's drone program.

Only a few countries, including the U.S., Britain and Israel, are known to have actually used armed drones in military operations.

"China is a bit of a tough nut to crack as you'd expect," said Huw Williams, a drone expert at Jane's International Defense Review. "They frequently wheel out exciting looking aircraft but are yet to really demonstrate anything earthshattering."

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